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clinmed/2002050001v1 (May 16, 2002)
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The influence of prelabor rupture of the membranes (PROM) on levels of oral mucosal immunoglobulins in the neonate

Bastian M. Seidel, Simone Schubert, Birgit Labitzke, and Michael Borte

Oral mucosal immunoglobulins play an important role in the human immune system as a first line defence against viral and bacterial infection. Secretory IgA, IgD and the free secretory component can be determined in the first days of life, however it is yet unknown which events influence the local synthesis of the immunoglobulins. The aim of this study was to evaluate the influence of prelabor rupture of the membranes (PROM) within a period of 24 hours on synthesis of oral mucosal sIgA, IgD, FSC and albumin of neonates in their first day of life. Comparison of 21 neonates with a history of PROM with a control group of 44 term neonates revealed no significant differences neither with respect to sIgA, IgD, FSC nor to albumin. The results indicate that PROM within a period of 24 hours does not significantly increase the synthesis of oral mucosal immunoglobulins in neonates in the first day of life.





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