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clinmed/2001010004v2/DS2
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Table 2 Number of events and relative risks (95% confidence intervals) for mortality in randomised controlled trials of vitamin A supplementation compared with placebo in measles patients

 

Number of events

 

 

Event and trial

Vitamin A group

Placebo group

Relative risk

(95% CI)

Tests for heterogeneity

Mortality (2 doses of 200 000 IU)

 

 

 

 

Barclay21

6/88

12/92

0.52 (0.16 to 1.40)

 

Hussey22

2/92

10/97

0.21 (0.02 to 0.95)

 

Coutsoudis23

0/29

1/31

0.00 (0.00 to 18.0)

 

Mortality (Single dose of 200 000 IU)

 

 

 

 

Rosales13

6/90

7/110

1.04 (0.29 to 3.2)

 

Ogaro14

5/146

3/148

1.68 (0.33 to 9.29)

 

Summary estimate for 1 dose13, 14

11/236

10/258

1.25 (0.48 to 3.1)

P=0.60

Summary estimate for 2 doses21, 22, 23

8/209

23/220

0.36 (0.14 to 0.82)

P=0.51

Summary estimate for 1 and 2 doses13, 14, 21, 22, 23 

19/445

33/478

0.61 (0.32 to 1.12)

P=0.26

*Summary estimate for 1 and 2 doses13, 14, 21, 22, 23, 19

30/745

59/778

0.53 (0.33 to 0.83)

P=0.21

Mortality (Formulation)

 

 

 

 

Water-based vitamin A summary estimate22, 23

2/121

11/128

0.19 (0.02 to 0.85)

P=0.67

Oil based vitamin A summary estimate13, 14, 21

17/324

22/350

0.84 (0.42 to 1.62)

P=0.33

Mortality in < 2 years (2 doses of 200 000 IU)

 

 

 

 

Barclay21

1/46

7/42

0.13 (0.002 to 0.95)

 

Hussey22

2/76

9/85

0.25 (0.02 to 1.14)

 

Coutsoudis23

0/29

1/31

0.0 (0.0 to 18.02)

 

Summary estimate for water and oil based21, 22, 23

3/151

17/158

0.17 (0.03 to 0.61)

P=0.79

Summary estimate for water based 22, 23

2/105

10/116

0.23 (0.02 to 1.008)

P=0.64

*Summary estimate for water and oil based21, 22, 23, 19

12/283

37/380

0.31 (0.15 to 0.60)

P=0.67

Mortality in 2 years (2 doses of 200 000 IU)

 

 

 

 

Barclay21

5/42

5/50

1.18 (0.27 to 3.88)

 

Hussey22

0/16

1/12

0.0 (0.0 to 8.71)

 

Summary estimate21, 22

5/58

6/62

0.94 (0.23 to 3.1)

P=0.23

*Summary estimate21, 22, 19

7/226

12/240

0.64 (0.20 to 1.76)

P=0.30

Pneumonia specific mortality (2 doses of 200 000 IU)

 

 

 

 

Barclay21

3/88

7/92

0.45 (0.06 to 1.83)

 

Hussey22

2/92

8/97

0.26 (0.02 to 1.26)

 

Coutsoudis23

0/29

1/31

0.0 (0.0 to 18.02)

 

Summary estimate (water and oil based)21, 22, 23

5/209

16/220

0.33 (0.08 to 0.92)

P=0.74

Summary estimate for water based vitamin A22, 23

2/111

9/128

0.23 (0.02 to 1.05)

P=0.63

Pneumonia specific mortality (1 dose of 200 000 IU)

 

 

 

 

Ogaro14

5/146

3/148

1.68 (0.33 to 9.29)

 

* Estimates are when the study by Ellison19 is included in the sensitivity analysis





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