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TABLE 1

Intrinsic imputability score – chronological criterion ( C ) e

Time to appearance of event Evolution when drug is curtailed	Highly suggestive (e.g. anaphylactic shock a few minutes after injection ; fetal malformation for which administration of suspect drug coincides with the precise period during which involved organ is formed)			Compatibility (eczema-type reaction occurring several days after taking incompatible drug)			Incompatibility (fixed pigmented erythema occurring several weeks after taking drug)
suggestive	C3	C3	C1	C3	C2	C1	C0
Inconclusive (regression which is spontaneous or induced by non-specific dermocorticoid anti-histaminic symptomatic treatment, irreversible lesions, insufficient follow- up, drug not curtailed because essential)	C3	C2	C1	C3	C1	C1	C0
Non-suggestive (absence of regression of reversible type of event or complete regression despite continuation of drug)	C1	C1	C1	C1	C1	C1	C0
	+	0	-	+	0	-	0
Relapse during involuntary re-administration of drug (0 = not performed )

Intrinsic imputability score – semiologic criterion (S)

semiology (clinical or para- clinical) : Other explanation not attributable to drug :		Evocative of role of drug ( and / or highly suggestive factor)							Other semiologic possibilities
Absent (after appropriate work- up )		S3		S3		S1			S3	S2	S1
Possible ( present or not sought)		S3		S2		S1			S3	S1	S1
+	0		-		+		0	-
Reliable specific complementary test ( 0 = test not available )

Intrinsic imputability score (I )
Chronology / Semiology	S1 doubtful	S2 plausible		S3 probable
C0 excluded	I0 excluded
C1 doubtful	I1 doubtful				I2 plausible
C2 plausible	I1		I2		I3
C3 probable	I3 probable				I4 very probable

Extrinsic imputability score (B)
B0 effect never published in inter- national reference documents, even after exhaustive bibliographic search	B1 effect not described in international reference works	B2 not well-known effect published once or twice only, different semiology or similar drug	B3 well-known effect described in the VIDAL dictionary or in reference works

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